Study of heterozygosity segments in the genomes of Russian sheep breeds
https://doi.org/10.26897/2074-0840-2025-4-12-14
Abstract
The paper presents the results of identifying regions of increased heterozygosity in the genomes of Karachaev and Romanov sheep based on whole-genome sequencing data. The presence and distribution of heterozygous segments in the breeds, including at the chromosomal level, are identified. Differences in the distribution of heterozygosity regions in the genomes of different breeds indicate the possible involvement of genes in these regions in the selection process that influences the development of economically significant traits.
About the Authors
A. S. Abdelmanova
Federal State Budgetary Budgetary Institution “Federal Research Center of Animal Husbandry – All-Russian Institute of Animal Husbandry named after academician L.K. Ernst”
Russian Federation
Russian Federation
Alexandra S. Abdelmanova, Senior researcher employee, Doctor of Biology sciences
142132, Moscow region, Podolsk city district, Dubrovitsy, 60
T. E. Deniskova
Federal State Budgetary Budgetary Institution “Federal Research Center of Animal Husbandry – All-Russian Institute of Animal Husbandry named after academician L.K. Ernst”
Russian Federation
Russian Federation
Tatiana E. Deniskova, leading researcher. employee, candidate of biology sciences
142132, Moscow region, Podolsk city district, Dubrovitsy, 60
M. S. Fornara
Federal State Budgetary Budgetary Institution “Federal Research Center of Animal Husbandry – All-Russian Institute of Animal Husbandry named after academician L.K. Ernst”
Russian Federation
Russian Federation
Margaret S. Fornara, Senior Researcher employee, candidate of biology sciences
142132, Moscow region, Podolsk city district, Dubrovitsy, 60
References
1. Liu S.Q., Xu Y.J., Chen Z.T., Li H., Zhang Z., Wang Q.S., Pan Y.C. Genome-wide detection of runs of homozygosity and heterozygosity in Tunchang pigs ● Animal, 2024. Vol.18 (8). Р. 101236. doi: 10.1016/j.animal.2024.101236.
2. Li G., Tang J., Huang J., Jiang Y., Fan Y., Wang X., Ren J. Genome-wide estimates of runs of homozygosity, heterozygosity, and genetic load in two Chinese indigenous goat breeds ● Front Genet., 2022. Vol. 13. Р. 774196. doi: 10.3389/fgene.2022.774196.
3. Ferrer E.S., García-Navas V., Sanz J.J., Ortego J. The strength of the association between heterozygosity and probability of interannual local recruitment increases with environmental harshness in blue tits ● Ecology and Evolution, 2016. Vol. 6. Рp. 8857-8869. doi: 10.1002/ece3.2591.
4. dos Santos W.B., Schettini G.P., Fonseca M.G., Pereira G.L., Chardulo L.A.L., Machado Neto O.R., Baldassini W.A., de Oliveira H.N., Curi R.A. Fine-scale estimation of inbreeding rates, runs of homozygosity and genome-wide heterozygosity levels in the Mangalarga Marchador horse breed ● J Anim. Breed Genet., 2021. Vol. 138. Рp. 161-173. doi: 10.1111/jbg.12508.
5. Williams J.L., Hall S.J.G., Del Corvo M., Ballingall K.T., Colli L., Ajmone Marsan P., Biscarini F. Inbreeding and purging at the genomic Level: the Chillingham cattle reveal extensive, non-random SNP heterozygosity ● Anim. Genet., 2016. Vol. 47. Рp. 19-27. doi: 10.1111/age.12376.
6. Mulim H.A., Brito L.F., Pinto L.F.B., Ferraz J.B.S., Grigoletto L., Silva M.R., Pedrosa V.B. Characterization of runs of homozygosity, heterozygosity-enriched regions, and population structure in cattle populations selected for different breeding goals ● BMC Genomics, 2022. Vol. 23 (1). Рp. 209. doi: 10.1186/s12864-022-08384-0.
7. Samuels D.C., Wang J., Ye F., He J., Levinson R.T., Sheng Q., Zhao S., Capra J.A., Shyr Y., Zheng W., Guo Y. Heterozygosity ratio, a robust global genomic measure of autozygosity and its association with height and disease risk ● Genetics, 2016. Vol. 204 (3). Рp. 893-904, doi: 10.1534/genetics.116.189936.
8. Chen Z., Zhang Z., Wang Z., Zhang Z., Wang Q., Pan Y. Heterozygosity and homozygosity regions affect reproductive success and the loss of reproduction: A case study with litter traits in pigs ● Comput Struct Biotechnol J., 2022. Vol. 20. Рp. 4060-4071. doi: 10.1016/j.csbj.2022.07.039.
9. Selli A., Ventura R.V., Fonseca P.A.S., Buzanskas M.E., Andrietta L.T., Balieiro J.C.C., Brito L.F. Detection and visualization of heterozygosity-rich regions and runs of homozygosity in worldwide sheep populations ● Animals, 2021. Vol. 11. Р. 2696. doi: 10.3390/ani11092696.
Review
For citations:
Abdelmanova A.S., Deniskova T.E., Fornara M.S. Study of heterozygosity segments in the genomes of Russian sheep breeds. Sheep, goats, wool business. 2025;(4):12-14. (In Russ.) https://doi.org/10.26897/2074-0840-2025-4-12-14
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