Analysis of polymorphisms associated with footrot in domestic and wild representatives of the genus ovis
https://doi.org/10.26897/2074-0840-2024-3-46-50
Abstract
The article presents the results of genotype determination in three target SNPs in the MPDZ gene, a potential candidate influencing the resistance of sheep to footrot, in representatives of domestic and wild Ovis. High-density SNP profiles generated for 15 local sheep breeds and 4 wild species of the genus Ovis were used as materials for the study. SNP profiles of 10 foreign breeds were added to the sample as comparison groups. Major and minor alleles in target SNPs (rs418747104, rs426927857, rs406749947) were determined. The influence of specific genotypes in target SNPs on resistance to footrot is discussed. In this study, we made the first attempt to understand the genetic mechanisms underlying resistance/susceptibility to footrot in domestic sheep breeds raised in Russia and wild representatives of the genus Ovis.
About the Authors
T. E. Deniskova
Federal State Budgetary Scientific Institution “Federal Research Center of Animal Husbandry – VIZ named after Academician L.K. Ernst”
Russian Federation
Russian Federation
Tatyana E. Deniskova, Ph D. Biol. sciences, Associate Professor, Leading Researcher of the Group of Genetics and Genomics of small cattle
tel.: (916) 914-20-17
60 Dubrovitsy village, Podolsk, Moscow region, 142132
A. V. Dotsev
Federal State Budgetary Scientific Institution “Federal Research Center of Animal Husbandry – VIZ named after Academician L.K. Ernst”
Russian Federation
Russian Federation
Arsen V. Dotsev, Ph D. Biol. sciences, Leading Researcher, Head of the Laboratory of Population and Evolutionary Genomics of Animals
tel.: (915) 316-79-65
60 Dubrovitsy village, Podolsk, Moscow region, 142132
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Review
For citations:
Deniskova T.E., Dotsev A.V. Analysis of polymorphisms associated with footrot in domestic and wild representatives of the genus ovis. Sheep, goats, wool business. 2024;(3):46-50. (In Russ.) https://doi.org/10.26897/2074-0840-2024-3-46-50
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